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Article

RXFP2 gene variation drives horn sexual differences and polledness in sheep.

Genomics - 1 May 2026

Hu Xiliu, Han Buying, Liu Dehui, Li Xue, Chen Cunxia, Xu Teng, Bao Guoxiang, Su Wanying, Li Guoxing, Li Rong, Xiang Xue, Ma Wulong, Zhao Kai, Tian Dehong

Abstract excerpt

This study performed deep sequencing of the RXFP2 gene in three sheep breeds: PT, QHS, and HS. Association analysis identified four significant variant loci: SNP25, SNP57, SNP70, and SNP28. GMDR and LASSO analyses confirmed the crucial role of SNP28 in horn trait regulation. Loci interaction analysis revealed an epistatic effect between SNP25 and SNP57, moreover further supporting that SNP25 may be a locus...

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Source

Identifiers

PMID: 41962598
DOI: 10.1016/j.ygeno.2026.111249

Genes

RXFP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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