Article
Regulation of Horn Development in Hu Sheep Involves RXFP2 Expression and Hormonal Signaling Independent of the 1.78-kb Insertion Genotype.
Animal genetics - 1 Apr 2026
Wang Haitao, Li Tingting, Chen Jieran, Wang Limin, Li Xia, Zhang Yuting, Zhang Na, Zhang Zhichao, Ma Runlin, Wang Daxiang, Huang Xun, Liu Qiuyue
Abstract excerpt
The RXFP2 gene is a key regulator of horn morphology in sheep (Ovis aries Linnaeus), with a 1.78-kb insertion in its 3'-untranslated region (UTR) previously linked to the polled phenotype. However, horned individuals homozygous for this insertion (1.78 kb+/+) have been observed in typically polled breeds such as Hu sheep, suggesting additional regulatory mechanisms. In this study, a significant horn-associated...
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