Article
Integration of a single-step genome-wide association study with a multi-tissue transcriptome analysis provides novel insights into the genetic basis of wool and weight traits in sheep.
Genetics, selection, evolution : GSE - 30 Jun 2021
Zhao Bingru, Luo Hanpeng, Huang Xixia, Wei Chen, Di Jiang, Tian Yuezhen, Fu Xuefeng, Li Bingjie, Liu George E, Fang Lingzhao, Zhang Shengli, Tian Kechuan
Abstract excerpt
BACKGROUND: Genetic improvement of wool and growth traits is a major goal in the sheep industry, but their underlying genetic architecture remains elusive. To improve our understanding of these mechanisms, we conducted a weighted single-step genome-wide association study (WssGWAS) and then integrated the results with large-scale transcriptome data for five wool traits and one growth trait in Merino sheep: mean...
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