Article
Expression profiling, functional characterization, and potential functional variants of the COL7A1 gene in sheep horn development.
Genomics - 1 Nov 2025
Zhang Shiwen, Li Hao, Meng Zhu, Liu Fei, Hu Yangshuo, Yang Huaiqiang, Mei Qiao, You Xiangbin, Wang Qiankun, Pan Zhangyuan, Yang Youbing
Abstract excerpt
The morphological diversity of sheep horns affects livestock production, yet its molecular regulation is poorly understood. COL7A1, essential for anchoring the epidermis to the dermis, was investigated using RNA-seq, WGS, and protein interaction prediction. COL7A1 was highly expressed in soft horn and skin, with higher levels in Scurred than Horned sheep (p < 0.05), suggesting a role in horn morphology....
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