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Article

Genetic architecture of postpartum psychosis: from common to rare genetic variation.

Molecular psychiatry - 1 Oct 2026

Jung Seulgi, Caballero Madison, Kępińska Adrianna, Smout Shelby, Munk-Olsen Trine, Robakis Thalia K, Bergink Veerle, Mahjani Behrang

Abstract excerpt

Postpartum psychosis is a severe psychiatric condition marked by the abrupt onset of psychosis, mania, or psychotic depression following childbirth. Despite evidence for a strong genetic basis, the roles of common and rare genetic variation remain poorly understood. Leveraging data from Swedish national registers and genomic data from the All of Us Research Program, we estimated family-based heritability at 55%...

Read the complete abstract on PubMed

Topics

Humans
Female
Psychotic Disorders
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Postpartum Period

Adult

Sweden

Polymorphism, Single Nucleotide

Registries

Schizophrenia

Bipolar Disorder

Whole Genome Sequencing

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 42135523
DOI: 10.1038/s41380-026-03637-w
PMCID: PMC13569460

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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