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Article

Impact of Typical Somatic Gene Mutation Characteristics on Homologous Recombination Deficiency in Breast Cancer.

Clinical breast cancer - 1 Jun 2026

Du Jinsui, Duan Chenglong, Zhang Jiaqi, Zhou Yudong, Wang Yalong, Zhu Lizhe, Li Junyi, Zhang Jianing, Pan Yi, Li Danni, Liu Zhihao, Zhang Chenrong, Zhang Yuhan, Ren Yu, Liu Xi, Wang Bin

Abstract excerpt

BACKGROUND: Homologous recombination deficiency (HRD) is an important contributor to genomic instability in breast cancer. This study aimed to characterize the mutational landscape of HRD breast cancer in a Shaanxi cohort and explore its clinicogenomic and immune microenvironment characteristics. METHODS: Gene mutation profiles were analyzed in 130 breast cancer patients, and HRD status were quantified using...

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Source

Identifiers

PMID: 42135153
DOI: 10.1016/j.clbc.2026.04.014

Genes

TP53
GSS
AR
BRCA1
BRCA2
FANCA
FOXC1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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