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Article

Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer.

Frontiers in immunology - 1 Jan 2024

Wang Zheng, Li Anqi, Lu Yujie, Han Mengyuan, Ruan Miao, Wang Chaofu, Zhang Xiaotian, Zhu Changbin, Shen Kunwei, Dong Lei, Chen Xiaosong

Abstract excerpt

The aim of this study was to evaluate the mutation spectrum of homologous recombination repair (HRR) genes and its association with tumor immune infiltration and prognosis in triple-negative breast cancer (TNBC). TNBC patients (434 patients from Ruijin cohort) were evaluated with targeted next-generating sequencing for mutations in HRR genes. The frequencies of mutations were compared with public reference...

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Identifiers

PMID: 39026672
DOI: 10.3389/fimmu.2024.1407837
PMCID: PMC11254810

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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