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Article

Predictive capacity of paediatric nasal epithelial cells in sequential CFTR modulator therapy.

Thorax - 14 May 2026

Fawcett Laura Katherine, Chew Zahra A, Schneider-Futschik Elena K, Allan Katelin M, Patel Hardip R, Jaffe Adam, Waters Shafagh

Abstract excerpt

BACKGROUND: CFTR modulators have transformed cystic fibrosis (CF) treatment, but individual responses vary even among patients with identical CFTR genotypes. This underscores the need for predictive biomarkers to optimise therapeutic selection. METHODS: We evaluated 24 paediatric patients homozygous for F508del-CFTR, assessing lung function (FEV1pp) and sweat chloride (SC) before and after CFTR modulator therapy....

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Identifiers

PMID: 42134857
DOI: 10.1136/thorax-2025-223153
PMCID: PMC13217057

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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