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Article

Advancing clinical development pathways for new CFTR modulators in cystic fibrosis.

Thorax - 1 May 2016

Mayer-Hamblett Nicole, Boyle Michael, VanDevanter Donald

Abstract excerpt

Cystic fibrosis (CF) is a life-shortening genetic disease affecting approximately 70,000 individuals worldwide. Until recently, drug development efforts have emphasised therapies treating downstream signs and symptoms resulting from the underlying CF biological defect: reduced function of the CF transmembrane conductance regulator (CFTR) protein. The current CF drug development landscape has expanded to include...

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Identifiers

PMID: 26903594
DOI: 10.1136/thoraxjnl-2015-208123
PMCID: PMC4853537

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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