Article

Clinical and primary cell evidence reveals complex CFTR function–phenotype relationships

2026-06-18

Abstract excerpt

<h4>Rationale</h4> The CFTR function-phenotype relationship remains incompletely understood, with prior work yielding heterogeneous findings suggesting linear and nonlinear associations. <h4>Objective</h4> Define the genotype-function-phenotype relationship using data from the Clinical and Functional TRanslation of CFTR (CFTR2) and human nasal epithelial (HNE) studies. <h4>Methods</h4> Clinical data (sweat ch...

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Literature Corpus work: 2ebb0c8f-9614-534e-9597-71fc4085991b
DOI: 10.64898/2026.06.17.732921

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