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Article

An Ultimate Question for Functional A-to-I mRNA Editing: Why Not a Genomic G?

Journal of molecular evolution - 1 Apr 2025

Xie Qiuhua, Duan Yuange

Abstract excerpt

A-to-I mRNA editing resembles A-to-G mutations. Functional mRNA editing, representing only a corner of total editing events, can be inferred from the experimental removal of editing. However, it is intuitive to ask why evolution chose RNA editing rather than directly (and simply) changing the genomic sequence to G? If G is better than A, then drift or constructive neutral evolution (CNE) theory can explain the...

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PMID: 39964487
DOI: 10.1007/s00239-025-10238-8

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