Neutralism and selectionism: a network-based reconciliation.

Abstract excerpt

Neutralism and selectionism are extremes of an explanatory spectrum for understanding patterns of molecular evolution and the emergence of evolutionary innovation. Although recent genome-scale data from protein-coding genes argue against neutralism, molecular engineering and protein evolution data argue that neutral mutations and mutational robustness are important for evolutionary innovation. Here I propose a...

Topics

• Animals
• Biological Evolution
• Evolution, Molecular
• Genetics, Population
• Genotype
• Humans
• Models, Genetic
• Mutation
• Selection, Genetic