Intraductal Papillary Squamous Neoplasm (IPSN) of the Pancreas: Histological and Molecular Characterization of a Novel and Distinct Intraductal Cancer Precursor.

doi:10.1016/j.modpat.2026.101011

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Article

Intraductal Papillary Squamous Neoplasm (IPSN) of the Pancreas: Histological and Molecular Characterization of a Novel and Distinct Intraductal Cancer Precursor.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2026

Bevere Michele, Pea Antonio, Adsay Volkan, Basturk Olca, Brosens Lodewijk A, Esposito Irene, Hruban Ralph H, Klimstra David, Hong Seung-Mo, Singhi Aatur D, Lee Seung Soo, Mattiolo Paola, Pasini Davide, Mafficini Andrea, Piccoli Paola, Pedron Serena, Ciulla Calogero, Brighenti Antonietta, Franzina Carlotta, Paiella Salvatore, Malleo Giuseppe, Salvia Roberto, Milella Michele, De Robertis Riccardo, D'Onofrio Mirko, Corbo Vincenzo, Lawlor Rita T, Scarpa Aldo, Luchini Claudio

Abstract excerpt

We report 6 intraductal papillary squamous neoplasms (IPSNs) of the pancreas, a rare but distinctive tumor whose biological features remain largely unknown. Five cases were investigated using an integrated approach combining histomorphological evaluation, immunohistochemistry, and multiregional molecular profiling through whole-exome DNA sequencing and whole-transcriptome RNA sequencing. Only targeted DNA...

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Identifiers

PMID: 42128055
DOI: 10.1016/j.modpat.2026.101011

Genes

CDKN2A
FGFR1
KMT2D
KRAS
MYC

Provenance

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