Article
Comparative performance of semi-quantitative methods for amyloid deposition in preclinical autosomal dominant Alzheimer's disease.
Alzheimer's research & therapy - 12 May 2026
Zhou Zhi, Gao Jin, Wang Qi, Wang Qigeng, Liu Linwen, Zhang Xiaojun, Li Can, Liu Jiajin, Wei Yidan, Zhang Shixiang, Wang Ruimin, Jia Jianping, Fu Liping
Abstract excerpt
BACKGROUND: Autosomal dominant Alzheimer's disease (ADAD) provides a unique window into the earliest stages of β-amyloid (Aβ) pathogenesis. However, it remains unclear whether standard Aβ positron emission tomography (PET) semi-quantitative methods, including the standardized uptake value ratio (SUVR), Z-scores, and the Centiloid (CL) scale, which were developed primarily for sporadic Alzheimer's disease (AD),...
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