Ceftazidime-avibactam drives mutations, insertion, or overexpression in blaKPC-2 and enhances biofilm-forming ability of KPC-producing Klebsiella pneumoniae.

Abstract excerpt

Although ceftazidime-avibactam (CZA) has known effectiveness against carbapenem-resistant Klebsiella pneumoniae (CRKP), its resistance is increasingly being reported. In this study, we explored the mechanisms behind this emerging resistance in CZA-resistant strains generated from 40 clinical K. pneumoniae carbapenemase (KPC)-producing CRKP through in vitro multipassage resistance selection with 1/2 MICs CZA. Of...

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