Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation.

Frontiers in immunology - 1 Jan 2026

Hu Chenhao, Sun Shengqiao, Li Dezhi, Yu Lebao, Guo Chao, Liu Song

Abstract excerpt

Objective: To elucidate causal roles of circulating immune cells and plasma proteins in diabetic peripheral neuropathy (DPN) pathogenesis using integrative Mendelian randomization (MR) and single-cell validation. Methods: We employed two-sample MR to assess causal effects of 731 immune traits and 4,719/2,923 plasma proteins on DPN risk (FinnGen: 2,843 cases/389,580 controls). Significant exposures underwent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendritic Cells
Share to Diabetic Neuropathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CAPS gene

Share to MICB gene

Share to Genetic Predisposition to Disease

Share to Mendelian Randomization Analysis

Share to Proteomics

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41694368
DOI: 10.3389/fimmu.2026.1681223
PMCID: PMC12894356

Genes

CAPS
MICB
AGER
CD79B
PRKCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoproteomic mediators of diabetic peripheral neuropathy: causal insights from Mendelian randomization and single-cell validation.PMID 41694368Read ↗

Integrating immune-cell transcriptomic data with Mendelian randomisation reveals novel causal genes for type 2 diabetes and its complications.Semantic proximity Read ↗

Transcriptome analysis combined with Mendelian randomization screening for biomarkers causally associated with diabetic retinopathySemantic proximity Read ↗

Causal role of immune cells in diabetic nephropathy: a bidirectional Mendelian randomization study.Semantic proximity Read ↗

Identification of biomarkers in diabetic neuropathy: a Mendelian randomization and bioinformatics analysis.Semantic proximity Read ↗

Immune Cell-Based Transcriptomic Mendelian Randomization and Colocalization Study on Type 1 DiabetesSemantic proximity Read ↗

Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study.Semantic proximity Read ↗

Immune cell phenotypes in the context of diabetic nephropathy: A Mendelian randomization analysis.Semantic proximity Read ↗

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis.Semantic proximity Read ↗

The effects of circulating proteins and metabolites on diabetic foot ulcer: A Mendelian randomization study and mediation analysis.Semantic proximity Read ↗

Uncovering Potential Genetic Targets in the Mediating Role of Demyelinating Disease for Multiple Sclerosis-Induced Neuropathic Bladder: A Mendelian Randomization AnalysisSemantic proximity Read ↗

Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genesSemantic proximity Read ↗

Mendelian randomization for autoimmune diseases: exploring causal links and drug targets in plasma proteomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.