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The potential causal relationship between BMI, T1D, urolithiasis, and hydronephrosis in European ancestry: A Mendelian randomization analysis.

Medicine - 27 Sept 2024

Han Yangjun, Gao Wenzhi, Wang Bing, Gao Zihui, Diao Mingxin, Zuo Chao, Zhang Minghua, Diao Yingzhi, Wang Chunji, Liu Honglei, Gu Yaming

Abstract excerpt

Body mass index (BMI), type 1 diabetes (T1D), urolithiasis, and hydronephrosis are interrelated. Our aim was to analyze their causal relationships at the genetic level. Mendelian randomization is an instrumental variable analysis method that follows Mendel genetic law of random allocation of parental alleles to offspring. In observational studies, genetic variants are used as instrumental variables to infer...

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Body Mass Index
Diabetes Mellitus, Type 1
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39331875
DOI: 10.1097/MD.0000000000039914
PMCID: PMC11441904

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