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Article

Real-world genetic testing data of ovarian cancer patients: Informing counseling and risk reduction in patients over age seventy.

Gynecologic oncology - 1 Jun 2026

Shachar Eliya, Rotkop Gilat, Haas Roni, Frankenthal Rachel, Kamara Daniella, Demirjian Maral, Kwan Lorna, Cummings Shelly, Roscow Breanna, Salani Ritu, Spellman Paul T, Karlan Beth, Chase Dana M

Abstract excerpt

BACKGROUND: Older women are underrepresented in hereditary cancer guidelines, and the prevalence of pathogenic or likely pathogenic (P/LP) germline variants in ovarian cancer (OC) patients aged ≥70 remains poorly characterized. Current recommendations for risk-reducing interventions and surveillance rely heavily on variant and family history (FH), yet their applicability in older populations is uncertain. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42114202
DOI: 10.1016/j.ygyno.2026.05.007
PMCID: PMC13322044

Genes

FH
BRCA1
ATM
BRCA2
BRIP1
PALB2
PMS2
RAD51C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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