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Article

Age of ovarian cancer diagnosis among BRIP1, RAD51C, and RAD51D mutation carriers identified through multi-gene panel testing.

Journal of ovarian research - 29 Apr 2021

Cummings Shelly, Roman Susana San, Saam Jennifer, Bernhisel Ryan, Brown Krystal, Lancaster Johnathan M, Usha Lydia

Abstract excerpt

BACKGROUND: Professional society guidelines recommend risk-reducing salpingo-oophorectomy (RRSO) for women with pathogenic variants (PVs) in ovarian cancer-risk genes. Personalization of that intervention is based on gene-specific phenotypes; however, the age of ovarian cancer diagnosis in women with PVs in moderate penetrance ovarian cancer-risk genes is not well characterized. Women who had hereditary cancer...

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Identifiers

PMID: 33926482
DOI: 10.1186/s13048-021-00809-w
PMCID: PMC8086272

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