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Article

Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls.

Gynecologic oncology - 1 Nov 2017

Lilyquist Jenna, LaDuca Holly, Polley Eric, Davis Brigette Tippin, Shimelis Hermela, Hu Chunling, Hart Steven N, Dolinsky Jill S, Couch Fergus J, Goldgar David E

Abstract excerpt

OBJECTIVES: Given the lack of adequate screening modalities, knowledge of ovarian cancer risks for carriers of pathogenic alterations in predisposition genes is important for decisions about risk-reduction by salpingo-oophorectomy. We sought to determine which genes assayed on multi-gene panels are associated with ovarian cancer, the magnitude of the associations, and for which clinically meaningful associations...

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Source

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Identifiers

PMID: 28888541
DOI: 10.1016/j.ygyno.2017.08.030
PMCID: PMC5801741

Genes

ATM
BRCA1
BRCA2
BRIP1
CHEK2
MSH2
MSH6
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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