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Article

Induced pluripotent stem cell-based modeling of hemolytic anemia in patients with compound heterozygous KLF1 mutations reveals defective erythroid differentiation.

Stem cell research & therapy - 11 May 2026

Pratumkaew Ponthip, Wattanapanitch Methichit, Viprakasit Vip, Kheolamai Pakpoom, Issaragrisil Surapol

Abstract excerpt

BACKGROUND: Transfusion-dependent hemolytic anemia caused by compound heterozygosity due to mutations in the erythroid Krüppel-like factor 1 (KLF1) gene is a rare and severe blood disorder. The clinical manifestations of the patient are mainly related to erythroid cells. Moreover, the roles of the identified KLF1 mutations in the pathophysiology of this disease remain unclear due to the lack of an appropriate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42108505
DOI: 10.1186/s13287-026-05057-7
PMCID: PMC13330193

Genes

KLF1
CD44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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