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Article

ZP2 pathogenic variants cause in vitro fertilization failure and female infertility.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2019

Dai Can, Hu Liang, Gong Fei, Tan Yueqiu, Cai Sufen, Zhang Shuoping, Dai Jing, Lu Changfu, Chen Jing, Chen Yongzhe, Lu Guangxiu, Du Juan, Lin Ge

Abstract excerpt

PURPOSE: The oocyte-borne genetic causes leading to fertilization failure are largely unknown. We aimed to identify novel human pathogenic variants (PV) and genes causing fertilization failure. METHODS: We performed exome sequencing for a consanguineous family with a recessive inheritance pattern of female infertility characterized by oocytes with a thin zona pellucida (ZP) and fertilization failure in routine in...

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PMID: 29895852
DOI: 10.1038/s41436-018-0064-y

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