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The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans

20 Mar 2023

Abstract excerpt

Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of reduced fertilization rates in assisted reproduction treatments (ARTs). Human ejaculate contains millions of spermatozoa with varying degrees of fertilization potential and genetic quality, of which...

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PMID: 37020592
DOI: 10.3389/fendo.2023.1135973

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