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Article

The transformative role of single-cell analysis in multifactorial disorders research.

Methods (San Diego, Calif.) - 1 Jul 2026

Wang Chih-Yang, Ko Ching-Chung, Kumar Sachin, Xuan Do Thi Minh, Lin Hui-Ru, Lee Yung-Kuo, Nguyen Ngoc Uyen Nhi, Yang Pei-Ming, Solomon Dahlak Daniel

Abstract excerpt

Multifactorial inherited disorders (MIDs) arise from complex interactions between polygenic risk and environmental exposures, presenting major challenges for mechanistic discovery, patient stratification, and targeted therapy development. While traditional approaches like genome-wide association studies (GWAS) and bulk omics profiling have identified broad associations, they often struggle to resolve the cellular...

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PMID: 41862065
DOI: 10.1016/j.ymeth.2026.03.009

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