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Genetic confirmation of terbinafine resistance in Trichophyton rubrum mediated by the squalene epoxidase Leu393Phe mutation via targeted gene replacement.

Medical mycology - 1 May 2026

Suzuki Shusaku, Ishii Masaki, Ohata Shinya, Mano Yoko, Furuya Nobuhiko

Abstract excerpt

Terbinafine (TBF) is a first-line allylamine antifungal used to treat dermatophytosis caused by Trichophyton species, targeting squalene epoxidase (SQLE). The recent emergence of TBF-resistant Trichophyton rubrum (T. rubrum) strains represents a significant global clinical challenge. Although the SQLE Leu393Phe substitution is a commonly reported resistance mechanism in Japan, direct genetic evidence...

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Identifiers

PMID: 42096519
DOI: 10.1093/mmy/myag044

Genes

SQLE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Genetic confirmation of terbinafine resistance in Trichophyton rubrum mediated by the squalene epoxidase Leu393Phe mutation via targeted gene replacement.PMID 42096519Read ↗

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