Article
Report of terbinafine resistant Trichophyton spp. in Italy: Clinical presentations, molecular identification, antifungal susceptibility testing and mutations in the squalene epoxidase gene.
Mycoses - 1 Aug 2023
Bortoluzzi P, Prigitano A, Sechi A, Boneschi V, Germiniasi F, Esposto M C, Romanò L, Pavan G, Matinato C, Veraldi S, Marzano A V, Grancini A
Abstract excerpt
BACKGROUND: Numerous reports of resistance to terbinafine in Trichophyton spp. from all over the world are arousing justified attention and concern. Point mutations in the gene that encodes the squalene epoxidase (SQLE) enzyme are responsible for these therapeutic resistances. OBJECTIVES: Primary objective of the study was to describe first isolates of Trichophyton spp. resistant to terbinafine among the patients...
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