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Article

APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis.

British journal of cancer - 1 Jun 2023

Long Xiaoran, Lu Huaiwu, Cai Mei-Chun, Zang Jingyu, Zhang Zhuqing, Wu Jie, Liu Xiaoshi, Cheng Lin, Cheng Jiejun, Cheung Lydia W T, Shen Zhen, Zhou Ying, Di Wen, Zhuang Guanglei, Yin Xia

Abstract excerpt

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a challenging disease due to its intrinsic chemoresistance. Immunotherapy is an emerging treatment option but currently impeded by insufficient understanding of OCCC immunophenotypes and their molecular determinants. METHODS: Whole-genome sequencing on 23 pathologically confirmed patients was employed to depict the genomic profile of primary OCCCs. APOBEC3B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36997661
DOI: 10.1038/s41416-023-02239-5
PMCID: PMC10206171

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