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Article

In vivo interaction proteomics reveal a novel p38 mitogen-activated protein kinase/Rack1 pathway regulating proteostasis in Drosophila muscle.

Molecular and cellular biology - 1 Feb 2014

Belozerov Vladimir E, Ratkovic Srdjana, McNeill Helen, Hilliker Arthur J, McDermott John C

Abstract excerpt

Several recent studies suggest that systemic aging in metazoans is differentially affected by functional decline in specific tissues, such as skeletal muscle. In Drosophila, longevity appears to be tightly linked to myoproteostasis, and the formation of misfolded protein aggregates is a hallmark of senescence in aging muscle. Similarly, defective myoproteostasis is described as an important contributor to the...

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Identifiers

PMID: 24277934
DOI: 10.1128/MCB.00824-13
PMCID: PMC3911512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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