Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status.

eLife - 30 Apr 2021

Diboun Ilhame, Wani Sachin, Ralston Stuart H, Albagha Omar Me

Abstract excerpt

Paget's disease of bone (PDB) is characterized by focal increases in disorganized bone remodeling. This study aims to characterize PDB-associated changes in DNA methylation profiles in patients' blood. Meta-analysis of data from the discovery and cross-validation set, each comprising 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Case-Control Studies
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Osteitis Deformans

Share to Osteoclasts

Source

Open in PubMed Open full text

Identifiers

PMID: 33929316
DOI: 10.7554/eLife.65715
PMCID: PMC8184208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status.PMID 33929316Read ↗

Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease statusSemantic proximity Read ↗

Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of BoneSemantic proximity Read ↗

Paget’s disease: a review of the epidemiology, etiology, genetics, and treatmentSemantic proximity Read ↗

Biology and Treatment of Paget's Disease of Bone.Semantic proximity Read ↗

Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.Semantic proximity Read ↗

Genetics of Paget’s disease of boneSemantic proximity Read ↗

Identification of clinical characteristics biomarkers for rheumatoid arthritis through targeted DNA methylation sequencingSemantic proximity Read ↗

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal WomenSemantic proximity Read ↗

[Paget's disease of bone: 1877-2023. Etiology, and management of a disease on epidemiologic transition].Semantic proximity Read ↗

Clinical value of DNA methylation markers in autoimmune rheumatic diseases.Semantic proximity Read ↗

Analysis of genetics and DNA methylation in osteoarthritis: What have we learnt about the disease?Semantic proximity Read ↗

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.