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Allostatic load, sleep patterns, and genetic susceptibility in relation to severe mental illness: A prospective cohort study.

Schizophrenia research - 1 Aug 2026

Liu Yuxuan, Wang Yingxue, Tian Susu, Hu Xinyi, Tian Jiayi, Wang Yihan, Mackay Louisa Esi, Wang Wei, Gao Can

Abstract excerpt

OBJECTIVES: Allostatic load (AL) and sleep patterns are linked to severe mental illness (SMI), though their exact mechanisms remain unclear. This study investigated the impact of AL, sleep behavior, and genetic susceptibility on the incidence of SMI (schizophrenia and bipolar disorder). METHODS: The study included 304,884 (schizophrenia) and 304,335 (bipolar disorder) participants from UK Biobank free of SMI at...

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PMID: 42066662
DOI: 10.1016/j.schres.2026.04.018

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