Article

Modeling Sleep Genetics Uncovers Distinct Disease Risks in Night vs. Day Workers

2025-09-08

Abstract excerpt

<title>Abstract</title> <p>Shift work has adverse health consequences, but the genetic basis of this vulnerability remains underexplored. Using Genomic structural equation modelling, we derived six latent sleep factors reflecting core RU-SATED domains from large-scale GWAS data. Polygenic scores for sleep regularity and daytime alertness showed strong genetic correlations with metabolic and behavioral traits and...

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Literature Corpus work: 65138901-ed17-5ae5-98bb-6a21f158c9df
DOI: 10.21203/rs.3.rs-7528705/v1

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