Article
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.
Nature genetics - 1 Feb 2017
Lane Jacqueline M, Liang Jingjing, Vlasac Irma, Anderson Simon G, Bechtold David A, Bowden Jack, Emsley Richard, Gill Shubhroz, Little Max A, Luik Annemarie I, Loudon Andrew, Scheer Frank A J L, Purcell Shaun M, Kyle Simon D, Lawlor Deborah A, Zhu Xiaofeng, Redline Susan, Ray David W, Rutter Martin K, Saxena Richa
Abstract excerpt
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders and all-cause mortality, affect 25-30% of adults worldwide. Although environmental factors contribute substantially to self-reported habitual sleep duration and disruption, these traits are heritable and identification of the genes involved should improve understanding of sleep, mechanisms linking sleep to disease and...
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