Article

MyoScore: a Genetically Anchored Transcriptomic Scoring System for Quantifying Human Skeletal Muscle Health

2026-05-20

Abstract excerpt

Muscle health varies continuously from optimal function to severe pathology, yet no unified genetic framework quantifies this spectrum objectively. Here we develop MyoScore, a transcriptomic scoring system derived from transcriptome-wide association studies of 27 muscle-related phenotypes in over one million participants. TWAS selects genes whose genetically regulated expression in skeletal muscle associates with...

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Literature Corpus work: 763c1eaf-5278-5bdc-8545-928f0f11f386
DOI: 10.64898/2026.05.11.26352204

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