Genome-wide cross-trait analysis reveals shared genetic architecture between inflammatory bowel disease and ankylosing spondylitis.

doi:10.1038/s41598-026-51117-6

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Article

Genome-wide cross-trait analysis reveals shared genetic architecture between inflammatory bowel disease and ankylosing spondylitis.

Scientific reports - 30 Apr 2026

Li Wulong, Liu Guang, Wei Dan, Zhu Zhicheng, Luo Qinghua

Abstract excerpt

Patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) are clinically closely related. They suffer from comorbidities, possibly attributed to a shared genetic structure. By utilizing the genome-wide association study (GWAS) data of IBD and AS as the study object, the overall and local genetic associations were first assessed by employing the linkage disequilibrium score regression (LDSC),...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

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Share to Polymorphism, Single Nucleotide

Share to Spondylitis, Ankylosing

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PMID: 42062459
DOI: 10.1038/s41598-026-51117-6
PMCID: PMC13324420

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