Article
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.
American journal of human genetics - 4 Mar 2021
Somineni Hari K, Nagpal Sini, Venkateswaran Suresh, Cutler David J, Okou David T, Haritunians Talin, Simpson Claire L, Begum Ferdouse, Datta Lisa W, Quiros Antonio J, Seminerio Jenifer, Mengesha Emebet, Alexander Jonathan S, Baldassano Robert N, Dudley-Brown Sharon, Cross Raymond K, Dassopoulos Themistocles, Denson Lee A, Dhere Tanvi A, Iskandar Heba, Dryden Gerald W, Hou Jason K, Hussain Sunny Z, Hyams Jeffrey S, Isaacs Kim L, Kader Howard, Kappelman Michael D, Katz Jeffry, Kellermayer Richard, Kuemmerle John F, Lazarev Mark, Li Ellen, Mannon Peter, Moulton Dedrick E, Newberry Rodney D, Patel Ashish S, Pekow Joel, Saeed Shehzad A, Valentine John F, Wang Ming-Hsi, McCauley Jacob L, Abreu Maria T, Jester Traci, Molle-Rios Zarela, Palle Sirish, Scherl Ellen J, Kwon John, Rioux John D, Duerr Richard H, Silverberg Mark S, Zwick Michael E, Stevens Christine, Daly Mark J, Cho Judy H, Gibson Greg, McGovern Dermot P B, Brant Steven R, Kugathasan Subra
Abstract excerpt
Whether or not populations diverge with respect to the genetic contribution to risk of specific complex diseases is relevant to understanding the evolution of susceptibility and origins of health disparities. Here, we describe a large-scale whole-genome sequencing study of inflammatory bowel disease encompassing 1,774 affected individuals and 1,644 healthy control Americans with African ancestry (African...
Topics
- Black or African American
- Aged
- Aged, 80 and over
- Calbindin 2