Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

A multilevel analysis of the genetic association between inflammatory bowel disease and primary sclerosing cholangitis.

European journal of gastroenterology & hepatology - 1 May 2026

Tang Luwei, Mo Jianwen, Ouyang Junjie, Li Weisheng

Abstract excerpt

BACKGROUND: Inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC) are recognized as interconnected immune disorders, necessitating comprehensive genetic analysis. METHODS: The research employed genome-wide association study (GWAS) data pertinent to IBD and PSC. Initially, linkage disequilibrium score regression alongside SUPERGNOVA was utilized to assess their genetic correlation. The genetic...

Topics

Humans
Cholangitis, Sclerosing
Genome-Wide Association Study
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Inflammatory Bowel Diseases
Linkage Disequilibrium
Phenotype
Colitis, Ulcerative
Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Source

Identifiers

PMID: 41524586
DOI: 10.1097/MEG.0000000000003116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A multilevel analysis of the genetic association between inflammatory bowel disease and primary sclerosing cholangitis.PMID 41524586Read ↗

Investigating the shared genetic basis of inflammatory bowel disease and systemic lupus erythematosus using genetic overlap analysis.Semantic proximity Read ↗

Integrative analysis of genetic and cellular interactions connecting inflammatory bowel disease and primary biliary cholangitis.Semantic proximity Read ↗

Genome-wide cross-trait analysis reveals shared genetic architecture between inflammatory bowel disease and ankylosing spondylitis.Semantic proximity Read ↗

Rare Comorbidity between Inflammatory Bowel Disease and Primary Biliary Cholangitis: Evidence from Causality, Shared Genetic Architecture and TranscriptomicsSemantic proximity Read ↗

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.Semantic proximity Read ↗

Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure.Semantic proximity Read ↗

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci.Semantic proximity Read ↗

Uncovering shared genetic features between inflammatory bowel disease and systemic lupus erythematosusSemantic proximity Read ↗

Evidence for the gut‐skin axis: Common genetic structures in inflammatory bowel disease and psoriasisSemantic proximity Read ↗

Multivariable genome-wide analysis elucidates the shared genetic architecture, immunosenescence features, and gut-origin therapeutic targets of ulcerative colitis-associated multisystem inflammation.Semantic proximity Read ↗

Cross-trait mapping of shared susceptibility across inflammatory bowel disease and spondyloarthropathies.Semantic proximity Read ↗

Multidimensional dissection of shared genetic susceptibility in ulcerative colitis and colorectal cancer: novel insights from integrative single-cell and multi-omics analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.