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Article

An engineered CRM197 variant with enhanced stability and efficacy.

International journal of biological macromolecules - 1 May 2026

Hu Enbo, Cao Chen, Chen Cheng, Zai Xiaodong, Wang Yanchun, Zhai Yanfang, Li Kai, Sang Shuli, Yu Weili, Wen Ying, Zhai Lina, Ye Xuanqi, Liu Yanhong, Cui ShiYing, Zhang Keyi, Mao Yunyun, Yu Rui

Abstract excerpt

Cross-Reacting Material 197 (CRM197), a non-toxic mutant of diphtheria toxin, is structurally similar and immunologically cross-reactive with the native toxin. It is extensively utilized as a carrier protein in conjugate vaccines to enhance T-cell-dependent immunity and also displays antitumor properties via interaction with heparin-binding epidermal growth factor (HB-EGF). Nevertheless, the structural...

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Identifiers

PMID: 42061529
DOI: 10.1016/j.ijbiomac.2026.152286

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EGF

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An engineered CRM197 variant with enhanced stability and efficacy.PMID 42061529Read ↗

Biochemical and biological characteristics of cross-reacting material 197 CRM197, a non-toxic mutant of diphtheria toxin: use as a conjugation protein in vaccines and other potential clinical applications.Semantic proximity Read ↗

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.Semantic proximity Read ↗

NMR study of mutations of glycine-52 of the catalytic domain of diphtheria toxin.Semantic proximity Read ↗

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.Semantic proximity Read ↗

Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.Semantic proximity Read ↗

Comparison of the diphtheria mutant toxin, CRM197, with a Haemophilus influenzae type-b polysaccharide-CRM197 conjugate by optical spectroscopy.Semantic proximity Read ↗

Use of imaged capillary isoelectric focusing technique in development of diphtheria toxin mutant CRM197.Semantic proximity Read ↗

Assessments of hepatitis B virus-like particles and Crm197 as carrier proteins in melioidosis glycoconjugate vaccinesSemantic proximity Read ↗

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