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Article

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.

Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2012

Malito Enrico, Bursulaya Badry, Chen Connie, Lo Surdo Paola, Picchianti Monica, Balducci Enrico, Biancucci Marco, Brock Ansgar, Berti Francesco, Bottomley Matthew James, Nissum Mikkel, Costantino Paolo, Rappuoli Rino, Spraggon Glen

Abstract excerpt

CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus. To understand the molecular basis for lack of toxicity...

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Identifiers

PMID: 22431623
DOI: 10.1073/pnas.1201964109
PMCID: PMC3325714

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Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.PMID 22431623Read ↗

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