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Article

The functionality of a therapeutic antibody candidate restored by a single mutation from proline to threonine in the variable region.

Human vaccines & immunotherapeutics - 15 Dec 2023

Hautiere Marie, Maffucci Irene, Costa Narciso, Herbet Amaury, Essono Sosthene, Padiolleau-Lefevre Séverine, Boquet Didier

Abstract excerpt

mAbs play an essential role in the therapeutic arsenal. Our laboratory has patented the Rendomab-B49 mAb targeting the endothelin B receptor (ETB). This G protein-coupled receptor plays a driving role in the progression of numerous cancers. We chimerized our mAb (xiRB49) to evaluate its preclinical therapeutic efficacy in different ETB+ tumor models with an antibody drug conjugate approach. As previously...

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Identifiers

PMID: 38012091
DOI: 10.1080/21645515.2023.2279867
PMCID: PMC10760395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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