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Article

Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.

Journal of biochemistry - 1 May 2015

Suzuki Keisuke, Mizushima Hiroto, Abe Hiroyuki, Iwamoto Ryo, Nakamura Haruki, Mekada Eisuke

Abstract excerpt

Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a ligand of EGF receptor, is involved in the growth and malignant progression of cancers. Cross-reacting material 197, CRM197, a non-toxic mutant of diphtheria toxin (DT), specifically binds to the EGF-like domain of HB-EGF and inhibits its mitogenic activity, thus CRM197 is currently under evaluation in clinical trials for cancer therapy. To...

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Identifiers

PMID: 25432160
DOI: 10.1093/jb/mvu079

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.PMID 25432160Read ↗

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