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Article

Mathematical modeling of mutant transferrin-CRM107 molecular conjugates for cancer therapy.

Journal of theoretical biology - 7 Mar 2017

Yoon Dennis J, Chen Kevin Y, Lopes André M, Pan April A, Shiloach Joseph, Mason Anne B, Kamei Daniel T

Abstract excerpt

The transferrin (Tf) trafficking pathway is a promising mechanism for use in targeted cancer therapy due to the overexpression of transferrin receptors (TfRs) on cancerous cells. We have previously developed a mathematical model of the Tf/TfR trafficking pathway to improve the efficiency of Tf as a drug carrier. By using diphtheria toxin (DT) as a model toxin, we found that mutating the Tf protein to change its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28065783
DOI: 10.1016/j.jtbi.2017.01.008
PMCID: PMC5310938

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