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Computationally efficient, exact, covariate-adjusted genetic principal component analysis by leveraging individual marker summary statistics from large biobanks.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2020

Wolf Jack M, Barnard Martha, Xia Xueting, Ryder Nathan, Westra Jason, Tintle Nathan

Abstract excerpt

The popularization of biobanks provides an unprecedented amount of genetic and phenotypic information that can be used to research the relationship between genetics and human health. Despite the opportunities these datasets provide, they also pose many problems associated with computational time and costs, data size and transfer, and privacy and security. The publishing of summary statistics from these biobanks,...

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PMID: 31797641
PMCID: PMC6907735

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