Back to search

Article

Phage Host Range Expansion Through Directed Evolution on Highly Phage-Resistant Strains of <em>Klebsiella</em> <em>pneumoniae</em>

2025-07-04

Abstract excerpt

Multidrug-resistant (MDR) strains of Klebsiella pneumoniae present an acute threat as they continue to disseminate globally. Phage therapy has shown promise as a powerful approach to combat MDR infections, but narrow phage host ranges make development of broad acting therapeutics more challenging. The goal of this effort was to use in vitro directed evolution (the “Appelmans protocol”) to isolate K. pneumoniae pha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2c7730e7-3f8f-57d6-aa22-9b05bb963f5c
DOI
10.20944/preprints202507.0366.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Phage Host Range Expansion Through Directed Evolution on Highly Phage-Resistant Strains of <em>Klebsiella</em> <em>pneumoniae</em>DOI 10.20944/preprints202507.0366.v1
Experimental Phage Evolution Results in Expanded Host Ranges Against MDR and XDR <i>Klebsiella pneumoniae</i> IsolatesSemantic proximity
PHENOTYPIC CHARACTERIZATION OF FIVE PHAGES ACTIVE AGAINST ANTIBIOTIC-RESISTANT KLEBSIELLA PNEUMONIAE.Semantic proximity
Bacteriophages of <i>Klebsiella</i> spp., their diversity and potential therapeutic usesSemantic proximity
Isolation and characterization of novel phages targeting pathogenic <i>Klebsiella pneumoniae</i>Semantic proximity
Evolutionary strategies of <i>Klebsiella</i> phages in a host-diverse environmentSemantic proximity
Harnessing Lytic Phages for Biofilm Control in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Causing Urinary Tract InfectionSemantic proximity
Investigating the phenotypic alterations associated with hypermucoviscous hypervirulent Klebsiella pneumoniae during phage resistance development.Semantic proximity
Targeted phage hunting to specific <i>Klebsiella pneumoniae</i> clinical isolates is an efficient antibiotic resistance and infection control strategySemantic proximity
Genomic and translational characterisation of Autographviridae phage SAKp26.2 for catheter-associated biofilm clearance in drug-resistant Klebsiella pneumoniaeSemantic proximity
Genomic Characterization of 30 Lytic <i>Klebsiella pneumoniae</i> BacteriophagesSemantic proximity
Phenotypic and genomic features shaping the activity of a novel T4-like phage against clinical multidrug-resistant Klebsiella pneumoniaeSemantic proximity
Preclinical characterization and in silico safety assessment of three virulent bacteriophages targeting carbapenem-resistant uropathogenic Escherichia coliSemantic proximity
Select a neighboring publication to make it the new centre.