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Comparison of the somatic mutations in breast carcinomas in sporadic and BRCA1 carrier patients through targeted next generation sequencing.

Human pathology - 1 Aug 2026

Barron Cynthia Reyes, Ramineni Madhurya, Finkelman Brian S, Zhang Huina, Turner Bradley M, Love Tanzy, Hicks David G, Wang Xi

Abstract excerpt

OBJECTIVES: Women who carry a germline mutation in BRCA1 have an increased lifetime risk of developing breast cancer (BC). Prior Next-Generation Sequencing (NGS) studies on BCs from patients with germline BRCA1 mutations (gBRCA1) were limited, mostly with small cohorts and had generally been conducted on unselected BC cases, which may bias the results. The goal of this study was to analyze the somatic mutational...

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Identifiers

PMID: 42055234
DOI: 10.1016/j.humpath.2026.106144

Genes

TP53
BRCA1
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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