Article
Preliminary results of targeted sequencing of BRCA1 and BRCA2 in a cohort of breast cancer families: New insight into pathogenic variants in patients and at‑risk relatives.
Molecular medicine reports - 1 Sept 2021
Saied Marwa H, Elkaffash Dalal, Fadl Reham, Haleem Reham Abdel, Refeat Amal, Ibrahim Inas, Tahoun Mona, Elkayal Alyaa, Tayae Eman
Abstract excerpt
Breast cancer (BC) is the most commonly diagnosed cancer worldwide and a major health concern in Egypt. There is a known association between pathogenic variants identified in breast cancer susceptibility gene (BRCA)1 and 2 and the risk of developing BC. However, the number of studies investigating mutations in BRCA1 and BRCA2 in Egypt remains limited. Thus, the aim of the present study was to investigate the...
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