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Article

Regulation of OTULIN ubiquitination by RNF6 alleviates asthma via mitigating epithelial-mesenchymal transition‑like phenotypic changes.

Biochemical pharmacology - 1 Aug 2026

Li Yue, Fan Mingwei, Wang Ke, Jiang Tianci, Cheng Zhe

Abstract excerpt

In asthma, chronic inflammation and injurious microenvironment drive bronchial epithelial cells to undergo epithelial-mesenchymal transition (EMT)‑like phenotypic changes. This process disrupts the epithelial barrier, and facilitates extracellular matrix deposition, thereby constituting a pivotal mechanism underlying irreversible airway remodeling. Ring Finger Protein 6 (RNF6), an E3 ubiquitin ligase, was highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42055142
DOI: 10.1016/j.bcp.2026.118015

Genes

RNF6
OTULIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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