Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sodium butyrate‐activated TRAF6‐TXNIP pathway affects A549 cells proliferation and migration

2 Oct 2019

Abstract excerpt

TNF receptor-associated factor 6 (TRAF6) promotes the development of human lung cancer through bridging RAS and NF-kB pathways; on the other hand, thioredoxin-interacting protein (TXNIP) suppresses the growth of tumors. However, the crosstalk between TRAF6 and TXNIP in non-small cell lung cancer (NSCLC) is currently unclear. Here, we found that TXNIP expression induced by sodium butyrate (NaBu) was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to interferon and immune responses
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31578830
DOI: 10.1002/cam4.2564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sodium butyrate‐activated TRAF6‐TXNIP pathway affects A549 cells proliferation and migrationPMID 31578830Read ↗

TRAF6 regulates tumour metastasis through EMT and CSC phenotypes in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Sennoside A represses the malignant phenotype and tumor immune microenvironment of non-small cell lung cancer cells by inhibiting the TRAF6/NF-κB pathway.Semantic proximity Read ↗

Regulation of OTULIN ubiquitination by RNF6 alleviates asthma via mitigating epithelial-mesenchymal transition‑like phenotypic changes.Semantic proximity Read ↗

USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4Semantic proximity Read ↗

TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradationSemantic proximity Read ↗

TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinomaSemantic proximity Read ↗

CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosisSemantic proximity Read ↗

C1QTNF6 regulates cell proliferation and apoptosis of NSCLC in vitro and in vivoSemantic proximity Read ↗

β‐arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-κB activation and autophagy induced by TLR3 and TLR4Semantic proximity Read ↗

SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth.Semantic proximity Read ↗

Functional Role of Asparaginyl Endopeptidase Ubiquitination by TRAF6 in Tumor Invasion and MetastasisSemantic proximity Read ↗

TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.