Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians.

PLoS neglected tropical diseases - 1 Apr 2026

Espasandin Isabela, Cardoso Cynthia Chester, Leal-Calvo Thyago, Mendes Mayara Abud, Latini Ana Carla Pereira, de Castro Samuel Henrique Malcher, Leturiondo André Luiz, Bezerra Ohanna Cavalcanti de Lima, Pinheiro Roberta Olmo, Sales Anna Maria, Moraes Milton Ozório, Kehdy Fernanda de Souza Gomes

Abstract excerpt

BACKGROUND: Autophagy is a crucial host defense mechanism against intracellular pathogens, including Mycobacterium leprae. Genetic variants in autophagy-related genes have been associated with susceptibility to leprosy, but their functional relevance remains incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS: We investigate the association of single nucleotide polymorphisms (SNPs) in three genes involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels

Share to Case-Control Studies

Share to GTP-Binding Proteins

Share to Leprosy

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mycobacterium leprae

Source

Open in PubMed Open full text

Identifiers

PMID: 42044188
DOI: 10.1371/journal.pntd.0014241
PMCID: PMC13120706

Genes

CACNA2D3
IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians.PMID 42044188Read ↗

Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines.Semantic proximity Read ↗

A Systemic Review and Meta-analysis on Natural Resistance-associated Macrophage Protein 1 (3'-Untranslated Region) and Nucleotide-binding Oligomerization Domain-2 (rs8057341) Polymorphisms and Leprosy Susceptibility in Asian and Caucasian Populations.Semantic proximity Read ↗

Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome.Semantic proximity Read ↗

Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.Semantic proximity Read ↗

Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseasesSemantic proximity Read ↗

Association of the rs2111234, rs3135499, rs8057341 polymorphisms in the NOD2 gene with leprosy: A case-control study in the Norte de Santander, Colombia population.Semantic proximity Read ↗

Genome-Wide Analysis of Protein-Coding Variants in Leprosy.Semantic proximity Read ↗

Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.Semantic proximity Read ↗

<i>ACTR1A</i>has pleiotropic effects on risk of leprosy, inflammatory bowel disease and atopySemantic proximity Read ↗

Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.Semantic proximity Read ↗

Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.Semantic proximity Read ↗

Leprosy as a genetic model for susceptibility to common infectious diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.