Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity.

Vaccine - 22 May 2007

Ohba Kenji, Yoshida Shinsuke, Zahidunnabi Dewan Md, Shimura Hiromi, Sakamaki Nozomi, Takeshita Fumihiko, Yamamoto Naoki, Okuda Kenji

Abstract excerpt

Many influenza vaccines targeted to hemagglutinin (HA) show efficient immunogenicity for protecting subjects against influenza virus infection. Major antigenic changes to HA molecules can help influenza virus to develop resistance against HA-targeted vaccines. DNA vaccines encoding conserved antigens protect animals against diverse subtypes, but their potency requires further improvement. We generated a DNA-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross Reactions
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza Vaccines

Share to Nucleocapsid Proteins

Share to Nucleoproteins

Share to Vaccines, DNA

Share to Viral Core Proteins

Source

Identifiers

PMID: 17403560
DOI: 10.1016/j.vaccine.2007.02.074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant influenza A virus nucleoprotein is preferentially localized in the cytoplasm and its immunization in mice shows higher immunogenicity and cross-reactivity.PMID 17403560Read ↗

A VLP Vaccine Induces Broad-Spectrum Cross-Protective Antibody Immunity against H5N1 and H1N1 Subtypes of Influenza A VirusSemantic proximity Read ↗

Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza VaccinesSemantic proximity Read ↗

Neuraminidase (NA) 370-Loop Mutations of the 2009 Pandemic H1N1 Viruses Affect NA Enzyme Activity, Hemagglutination Titer, Mouse Virulence, and Inactivated-Virus Immunogenicity.Semantic proximity Read ↗

DNA Vaccine that Targets Hemagglutinin to MHC Class II Molecules Rapidly Induces Antibody-Mediated Protection against InfluenzaSemantic proximity Read ↗

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodiesSemantic proximity Read ↗

Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic driftSemantic proximity Read ↗

Protective Efficacy of the Conserved NP, PB1, and M1 Proteins as Immunogens in DNA- and Vaccinia Virus-Based Universal Influenza A Virus Vaccines in MiceSemantic proximity Read ↗

Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine developmentSemantic proximity Read ↗

Non-neutralizing antibody responses to vesicular stomatitis virus-vectored influenza A virus vaccines correlate with protectionSemantic proximity Read ↗

T-Cell Immunity to Influenza A VirusesSemantic proximity Read ↗

Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T-cell responses.Semantic proximity Read ↗

An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.