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Article

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

16 Aug 2018

Abstract excerpt

Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal...

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PMID: 30135514
DOI: 10.1038/s41467-018-05482-0

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